Who we are
As a biotech startup spun out from Newcastle University in 2019, 3D Bio-Tissues (3DBT) is at the forefront of producing bio-equivalent tissues for clinical and cellular agriculture. We apply novel bio-inspired manufacturing processes to generate complex structures.
Powered by BSF Enterprise
3DBT is a wholly-owned subsidiary of BSF Enterprise PLC—a listed (LON: BSFA) biotech investor focused on the development of the next generation of cutting-edge biotech solutions. BSF Enterprise aims to radically transform the delivery of sustainable solutions across a variety of sectors including tissue engineering.
Background
Our technology is built upon 20 years of basic research
Applying the hypothesis that a better understanding of biology will lead to improved approaches to tissue engineering we have developed a powerful new process we call TISSUE TEMPLATING
Tissue templating is an in-house engineering platform that takes a bio-inspired, bottom-up approach to tissue engineering to create STRUCTURED, FUNCTIONAL and SCALABLE tissues
Our products
Summary
Structured
Our tissue templating approach to engineering tissues is cell based. Highly organised structures with an accurate nano-scale through to macro-scale ensue.
Functional
Engineered tissue with appropriate hirearchical ECM arrangement produces unrilvaled performance and functionality.
Scalable
Our production suits a traditional centralised manufacturing approach, in which 100's of tissue engineered products can be produced daily and without the use of animal components.
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Tissue structure is incredibly complex, from nano through to macro scales
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Hierarchical organisation is essential to all tissue structures
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Appropriate structure = Proper function
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Accurately replicating nanoscale organisation of tissue ultrastructure is a considerable engineering challenge
The
Problem
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Apply physical and biochemical cues to direct/orgainse cells growth
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Use the inherent power of cells
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Self-assembling cells form highly structured natural tissues
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Serum free culture conditions
Platform Technology
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Use the inherent power of cells to engineer tissue
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Nanoscale resolution
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Hierarchical structure
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Physiological function
The Solution
Technology built upon science
Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
RM Gouveia, G Lepert, S Gupta, RR Mohan, C Paterson, CJ Connon 2019
Nature communications 10 (1), 1-17
4D Corneal Tissue Engineering: Achieving Time‐Dependent Tissue Self‐Curvature through Localized Control of Cell Actuators
M Miotto, RM Gouveia, AM Ionescu, F Figueiredo, IW Hamley, CJ Connon 2019
Advanced Functional Materials 29 (8), 1807334
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Template curvature influences cell alignment to create improved human corneal tissue equivalents
RM Gouveia, E Koudouna, J Jester,
F Figueiredo, CJ Connon 2017
Advanced Biosystems 1 (12), 1700135
Contact
If you have any questions at all
Don't hesitate to ask.
For any media enquiries, please contact the SEC Newgate team on 3DBT@secnewgate.co.uk.
