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Who we are

  • We're a Bio-Tech startup, spun-out from Newcastle University in 2019

  • Our ambition is to produce bio-equivalent tissues for clinical and cellular agriculture

  • We apply novel bio-inspired manufacturing processes to generate complex structures

 
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Who's who

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Dr Che Connon

CEO

Dr Che Connon - Che has over 20 years experience in extracellular matrix biology and is currently Professor of Tissue Engineering. He is also a seasoned entrepreneur having successfully spun out 3 bio-tech companies

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Dr Ricardo Gouveia

CSO

Dr Ricardo Gouveia - Ricardo is a New Harvest Research Fellow and the company’s co-founder. He is an expert in cell biology and biomaterials

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Dr Miguel Jarrin

R&D Scientist

Dr Miguel Jarrin - Experienced cell biologist in the cornea and lens, Miguel is responsible for tissue production

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Dr Rachel Sanders

R&D Technician

Dr Rachel Sanders - Our newest recruit, Rachel recently obtained her PhD from Edinburgh University in molecular biology

 
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Background

Our technology is built upon 20 years of basic research

 

Applying the hypothesis that a better understanding of biology will lead to improved approaches to tissue engineering we have developed a powerful new process we call TISSUE TEMPLATING

 

Tissue templating is an in-house engineering platform that takes a bio-inspired, bottom-up approach to tissue engineering to create STRUCTURED, FUNCTIONAL and SCALABLE tissues

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Summary

Structured

Our tissue templating approach to engineering tissues is cell based. Highly organised structures with an accurate nano-scale through to macro-scale ensue.

Functional

Engineered tissue with appropriate hirearchical ECM arrangement produces unrilvaled performance and functionality.

Scalable

Our production suits a traditional centralised manufacturing approach, in which 100's of tissue engineered products can be produced daily and without the use of animal components.

 

The

Problem

The Problem

  • Tissue structure is incredibly complex, from nano through to macro scales

  • Hierarchical organisation is essential to all tissue structures

  • Appropriate structure = Proper function

  • Accurately replicating nanoscale organisation of tissue ultrastructure is a considerable engineering challenge

Platform Technology

Platform

Technology

  • Apply physical and biochemical cues to direct/orgainse cells growth

  • Use the inherent power of cells

  • Self-assembling cells form highly structured natural tissues

  • Serum free culture conditions

The

Solution

The Solution

  • Use the inherent power of cells to engineer tissue

  • Nanoscale resolution

  • Hierarchical structure

  • Physiological function

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Technology built upon science

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Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

RM Gouveia, G Lepert, S Gupta, RR Mohan, C Paterson, CJ Connon 2019

Nature communications 10 (1), 1-17

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4D Corneal Tissue Engineering: Achieving Time‐Dependent Tissue Self‐Curvature through Localized Control of Cell Actuators

M Miotto, RM Gouveia, AM Ionescu, F Figueiredo, IW Hamley, CJ Connon 2019

Advanced Functional Materials 29 (8), 1807334

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Template curvature influences cell alignment to create improved human corneal tissue equivalents

RM Gouveia, E Koudouna, J Jester,
F Figueiredo, CJ Connon 2017

Advanced Biosystems 1 (12), 1700135

 

Contact

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If you have any questions at all

Don't hesitate to ask.

che.connon@3dbiotissues.com

Thanks for submitting!

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