City-Mix™ is composed of a specific formulation of inert, food-safe, and bio-sustainable macromolecules with the unique capacity to mimic naturally crowded environments and highly efficient bioprocesses within living organisms.

 

By occupying space within aqueous solutions, macromolecular crowders create volume-exclusion effects shown to enhance the thermodynamic activity and stability of biomolecules such as proteins. This means that City-Mix™ can effectively boost the performance of a wide variety of cell cultures by promoting the bioactivity and/or bioavailability of growth factors, protein carriers, and enzymes contained within the culture medium.

 

By mimicking the in vivo environment we see several important changes in cell behaviour, namely;

• Cellular proliferation rates increase, significantly increasing yield. 

• Less supplements are required, reducing the need for expensive growth factors and recombinant proteins.

• Facilitates tissues production via extracellular matrix establishment.

• Helps reduce or eliminate the need for animal-derived ingredients (e.g., FBS, albumin) while maintaining media performance.